45.5 + [2.3 x (number of inches over 5ft tall)] for females, 50 + [2.3 x (number of inches over 5ft tall)] for males, ((Actual Body Weight - Ideal Body Weight) x 0.40) + Ideal Body Weight, If BMI <25, use actual body weight in calculation, If BMI is 25, then use adjusted body weight for calculation, [(140-Age) x (Actual Body Weight)]/ (72 x SCr), The CrCl (GFR) will be capped at 125mL/min in the equation. The carboplatin dose calculator uses the Calvert formula to find the exact dosage according to your age, sex, and weight. Now we know the GFR value of the patients using the target AUC which is around 7 mg/ml/min, we can find the dosage of the Carboplatin of the patient. The calculation of the ideal body weight by Devines formula: Male = (50 kg if male or 45.5 if female) + (2.3 x (Height in inches - 60)). Please note that dose is provided in mg not mg/m 2. Health Calculators Carboplatin Calculator, For further assistance, please Contact Us. The median age was 57 years (range, 37 to 71). There is another dosing method, that involves body surface area, however, this is not as accurate. In overweight and obese patients, body weight applied to serum creatininebased formulas may overestimate glomerular filtration rate. This carboplatin dosing calculator uses the Calvert method to calculate the total carboplatin dose needed to achieve a given AUC (area under the free carboplatin plasma concentration versus time curve) while taking into account renal function. A limitation of the Calvert formula is that the carboplatin dosage can substantially vary, depending on the SCr-based formula used to estimate GFR (ie, Cockcroft-Gault, Jelliffe, or Modification of Diet in Renal Disease [MDRD]). A dosage formula has been derived from a retrospective analysis of carboplatin pharmacokinetics in 18 patients with pretreatment glomerular filtration rates (GFR) in the range of 33 to 136 mL/min. Carboplatin dose is based on the Calvert formula: The carboplatin dosage value takes account of the target area concentration versus time curve and estimated GFR. The ideal weight result is converted in both kg and lbs for convenience, where (1 kg = 2.20462262 lbs). Author Disclosure Statement The Body Surface Area of a person can be calculated according to the health and weight of a person and it is used for carboplatin. This tool estimates the total Carboplatin dose (in mg) based on the Cockcroft Gault equation which provides the estimated creatinine clearance level which is then adjusted by the target AUC. Data collection included demographic information, pretreatment and posttreatment complete blood count and nadir, concurrent cytotoxic chemotherapy, and any supporting documentation confirming treatment delays and dose reductions. Carboplatin AUC Dose for Female Solution STEP 0: Pre-Calculation Summary Formula Used Carboplatin AUC Dose for Female (mg) = Target AUC* (GFR for female (mL/min)+25) Carbo Dose = AUC* (GFR+25) This formula uses 3 Variables Variables Used August 9, 2006. Chatelut E, Canal P, Brunner V, et al. The carboplatin AUC dose calculation does involve your actual body weight and its comparison with the ideal body weight. To calculate carboplatin dose, the modified Calvert formula was used: dose (mg/m 2) = target AUC (raw GFR (mL/min) + 15 body surface area (BSA) (m 2)). Thirty patients were excluded based on criteria for low body weight, ideal body weight, or missing laboratory parameters; therefore, 20 patients were included in the final analysis (Figure). Thadhani R, Pascual M, Bonventre JV. Stable kidney function was defined by SCr change from baseline of <0.5 mg/dL.8. We defined treatment delays as 7 days from the planned day of carboplatin administration. We do consider the actual body weight and compare it to the ideal body weight to find the chemo dosage. Carboplatin AUC dose. Gender. Disable your Adblocker and refresh your web page . The IBW can be calculated by the, carboplatin dose calculator using creatinine clearance or adjusted body weight(ABW). The doubletcombination regimens included paclitaxel (N = 8), gemcitabine (N = 3), pemetrexed (N = 2), and etoposide (N = 1). What is AUC in carboplatin dosing? None of our prescribers utilized the MDRD or the Jelliffe formula to estimate GFR. The carboplatin calculator can be used to find the exact dosage for patients of various age groups. AUC = target area under the concentration versus time curve in mg/mLmin. Prediction of carboplatin clearance from standard morphological and biological patient characteristics. For a given time interval (t 1 - t 2 ), the AUC can be calculated as follows: In essence the first two terms calculate the average concentration over the time interval. This formula can be used to calculate the carboplatin dose accurately in order to obtain a target AUC by using only the GFR. Specifically, we identified the SCrbased formula used by the physician prescriber to estimate the GFR and body weight (ie, actual, ideal, adjusted) applied to the SCr-based formula, and whether a maximal/capped creatinine clearance (CrCl) rate was determined at the discretion of the prescriber. This information was gathered from a preprinted chemotherapy order form that included calculations for estimated renal function and the body weight descriptor applied. Patient data were accessed through electronic medical records. Carboplatin: 300 mg/m2 by IV on day 1 every 4 weeks for 6 cycles (alternatively, the carboplatin dose may be calculated by the Calvert formula below) Cyclophosphamide 600 mg/m2 IV on day 1 every 4 weeks for 6 cycles Carboplatin. BSA (m) = { [ height (cm) x weight (kg)] / 3600 }. So, carboplatin dosage is calculated using individual patient's renal function and AUC Because carboplatin dosing method is different from other chemotherapeutic agents dosing methods, evaluation of accuracy of dosage calculation and pharmacist's dosage check may be nec- essary. Acute renal failure (letter). Carboplatin is an antineoplastic agent that interferes with DNA replication and cell division. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. Calvert AH, Newell DR, Gumbrell LA, et al. Maximum Carboplatin Dose (mg) = target AUC (mg/mL per min) x (125 mL/min + 25) For a target AUC = 6, the maximum dose is 6 x 150 = 900 mg For a target AUC = 5, the maximum dose is 5 x 150 = 750 mg For a target AUC = 4, the maximum dose is 4 x 150 = 600 mg (See FDA communication on carboplatin dosing) Dosage with Toxicity: OncPharm.com assumes no liability of any kind for the information provided - all information provided should be validated by the user. Schmitt A, Gladieff L, Lansiaux A, et al. Patients were categorized based on actual body weight (kg) and height (cm) into 1 of 5 groups, including: Body weight categories are based on the National Institutes of Health guidelines on the identification of overweight and obese adults.9 Study analysis for end points included overweight, obese, and extremely obese patients. Sherif Abdou, Pharm.D, Northwestern Memorial It is important to note that in some cases with fluctuant serum creatinine, the estimation may not be as exact, thus it wont lead to an accurate Carboplatin dose either. If the number is greater than k apply classifier A. Carboplatin dosage calculator (Area under the curve - carboplatin clearance) Carboplatin dosage is calculated from sex, age, weight . Clinical pharmacokinetics and dose optimization of carboplatin. GFR by using creatinine clearance via a 24h urine collection, or more conveniently, by calculating the GFR with serum . There are certain conditions when using the Calvert formula:: There are separate formulas used in the carbo AUC calculator for men and for women. Of note, this patient was extremely obese with a BMI of 48.5 kg/m2. We identified the serum creatininebased formula utilized, the body weight descriptor applied to the glomerular filtration rate formula, and whether a maximal/capped creatinine clearance rate was determined. . We always struggled to serve you with the best online calculations, thus, there's a humble request to either disable the AD blocker or go with premium plans to use the AD-Free version for calculators. There can be fluctuating results of CrCl values in patients and the Calvert formula should not be used here. A universal formula based on cystatin C to perform individual dosing of carboplatin in normal weight, underweight, and obese patients. Furthermore, in overweight and obese populations, body weight (actual body weight vs ideal body weight) applied to an SCr-based formula may overestimate GFR. 3. The carboplatin dose calculator uses creatinine clearance taking into account the body surface area of the patients. Everybody needs a calculator at some point, get the ease of calculating anything from the source of calculator-online.net. R AUC . J Clin Oncol. Since AUC-5/6 patients received significantly higher carboplatin doses than AUC-2 patients, we analysed these two groups separately (i.e., AUC-2 and AUC-5/6). Carboplatin dosage relies on glomerular filtration rate (GFR) and area under the curve (AUC). Common Terminology Criteria for Adverse Events, v3.0S. By using this form you agree with the storage and handling of your data by this website. For that, you can also use the carboplatin calculator. The equation is: carboplatin dose (mg) = AUC [GFR + 25]. Patients outside the normal weight range should not be treated by the Calvert formula. 2. Prediction of creatinine clearance from serum creatinine. A practical guide on how to calculate AUC from pharmacokinetic data. Based on data from Jodrell and colleagues in patients with ovarian cancer, the expected incidence of grade 3 thrombocytopenia for carboplatin AUC 4 to 5 is 5%, AUC 5 to 6 is 10%, and AUC 6 to 7 is 20%.19. Did you face any problem, tell us! Evaluation of the Modified Diet in Renal Disease Equation for calculation of carboplatin dose. Patients were excluded if baseline laboratory values were not available. The Jelliffe equation is usually used to find the changes in the serum or creatinine level over a period of time. The results you receive from this tool are for informational purposes only and should not be Added bonus? To be able to investigate this further we defined the variable 'delivered AUC' (dAUC) for carboplatin as: the delivered dose at cycle 1 full dose (according to an uncapped/'unbanded' eGFR from the CG formula using IDMS SCr and ABW) 6. The dose depends upon the function of the kidneys. Future considerations include designing a prospective study evaluating body weight descriptors (ideal vs adjusted) to estimate GFR for use in the Calvert formula incorporating measured carboplatin AUCs compared with target AUCs to identify dose divergence and subsequent adverse clinical events in this population. DICP. Carboplatin dose (mg) = AUC (GFR + 25) Carboplatin dose (mg) = 7 (81.25 + 25) Carboplatin dose (mg) = 7 106.25 Carboplatin dose (mg) = 743.8 AUC 5 = 750 mg . Ekhart C, Rodenhuis S, Schellens JH, et al. of every-three-week carboplatin during paclitaxel, or c) the addition of carboplatin and the oral poly (ADP-ribose) inhibitor veliparib during paclitaxel . Calculate carboplatin dose by Calvert formula, mg = AUC (GFR + 25) (substitute CrC l for GFR in. Increased awareness and education regarding unique considerations with the Calvert formula in overweight and obese populations should be directed to medical oncology physician prescribers, pharmacists, and healthcare providers within the oncology community to establish quality assurance within the institution or practice site. The carboplatin calculator helps to find the dosage of the carboplatin according to the age, sex, and body weight of a patient. Legal action may follow for reproduction of materials without permission. This formula has proven to be, in both retrospective and prospective studies, a reliable tool to calculate the optimal dose of carboplatin Future studies should determine the value of the creatinine clearance as a measure for the GFR. Herrington JD, Tran HT, Riggs MW. 1. Objective: The primary objective of this study was to evaluate physician prescribing practices with the Calvert formula in overweight and obese patients. The GFR used to calculate the AUC dosing should not exceed 125ml/min (3). The GFR estimates how much blood passes through the Glomeruli per minute. Scott Wirth, Pharm.D, BCOP, University of Illinois Despite the study limitations, our results contribute to existing data regarding prescribing patterns within our institution and highlight unique considerations when calculating carboplatin dosage with the Calvert formula in overweight and obese patients. Overestimation may result in divergent carboplatin dosages that correlate with dose-limiting thrombocytopenia, treatment delays, and dose reductions. Carboplatin dosage relies on glomerular filtration rate (GFR) and area under the curve (AUC). AUC (Area Under the Curve) - the area under the pharmacokinetic curve - the concentration-time curve (change in the concentration of the active substance in plasma or serum over time). IBW (males) = 50 kg + 2.3 x (height [inches] 60), IBW (females) = 45.5 kg + 2.3 x (height [inches] 60). Carboplatin is excreted almost exclusively by the kidneys. The study demographics included mean age of 62.3 years, and more whites than blacks comprised the study population. Carboplatin - Clinical Pharmacology This online calculator allows you to find the AUC of carboplatin . Patient gender to be used in the Cockcroft Gault equation and in Devines formula; Patient age in years, to be used in the Cockcroft Gault equation; Patient weight can be input in either lbs or kg; Patient height can be specified in either ft and in or cm; Serum creatinine measured in mg/dL or mol/L; Target AUC expected values range between 4 and 8 mg/mL/min; The Cockcroft and Gault equations when serum creatinine is in mg/dL: CrCl for male = [(140 - age) x Weight in kilograms] / (Serum Creatinine in mg/dL x 72), CrCl for female = [(140 - age) x Weight in kilograms x 0.85] / (Serum Creatinine in mg/dL x 72). Use the Cockcroft and Gault method to calculate estimated creatinine clearance: CrCl = (140 - age) x wt. It is virtually insoluble in ethanol, acetone, and dimethylacetamide. Based on the Calvert formula described in the carboplatin label, the maximum doses can be calculated as: Maximum Carboplatin Dose (mg) = Target AUC (mg/mL/min) x (125 mL/min + 25) For a target AUC = 6, the maximum dose is 6 x 150 = 900 mg For a target AUC = 5, the maximum dose is 5 x 150 = 750 mg Approximately 65% to 70% of the total platinum dose is eliminated as intact carboplatin in the urine during the first 12 to 16 hours after administration.1. The study by Herrington and colleagues demonstrated that the optimal weight to use for obese patients, defined as a BMI >30 kg/m2 with renal function and SCr within normal limits, was adjusted body weight.3 Using actual body weight in SCr-based formulas for the Calvert formula resulted in carboplatin AUCs 30% to 40% higher than predicted or targeted AUCs.3 The study results are limited because, despite evaluating actual versus targeted carboplatin AUC divergence in overweight and obese patients, the investigators did not objectively evaluate the impact of a supratherapeutic carboplatin AUC on clinical outcomes, such as doselimiting myelosuppression or treatment delays.3. This process is called Scoring. Carboplatin Dose (mg) Developed by : Sherif Abdou, Pharm.D, Northwestern Memorial Scott Wirth, Pharm.D, BCOP, University of Illinois Andrew Crawford, Pharm.D, University of Illinois Sandra Cuellar Puri, Pharm.D, BCOP, University of Illinois Relevant package insert data: Now we know the GFR value of the patients using the target AUC which is around 7 mg/ml/min, we can find the dosage of the Carboplatin of the patient. carboplatin clearance for Female = (0,134xweight)+0.686x (218xweightx (1-0.00457xage)/serum cr?t.) Carboplatin dose (mg) = AUCx (GFR + 25) Carboplatin dose (mg) = 7 x (81.25 + 25) Carboplatin dose (mg) = 7 x 106.25 Jakobsen A, Bertelsen K, Andersen JE, et al. The most relevant pharmacokinetic parameter for drug exposure is the area under the curve (AUC) of plasma concentration x time following a single dose. Add this calculator to your site and lets users to perform easy calculations. AUC = target area under the concentration versus time curve in mg/mLmin. For 70-year-old people, the normal range of GFR is around 60 mL/min/1.73 m2. = AUC (mg/ml x min) x carboplatin clearance (ml/min) AUC = Area Under the Curve; carboplatin clearance for Male = (0,134xweight)+(218xweightx(1-0.00457xage)/serum creat.) CrCl for serum creatinine in mg/dL = [(140 - age) x Weight in kilograms (x 0.85 if female)] / (Serum Creatinine in mg/dL x 72), CrCl for serum creatinine in mol/L = [(140 - age) x Weight in kilograms x (1.23 if male or 1.04 if female)] / (Serum Creatinine in mol/L). The Cockcroft-Gault equation normally uses the total body weight, but this equation also uses the Ideal body weight in the advanced version of the calculations. NCCP Chemotherapy Regimen NCCP Regimen: Carboplatin (AUC 2) Plus RT Published: 11/05/2017 Review: 03/02/2026 1. in kg x 1.00 (male) OR x 0.85 (female) 72 x serum creatinine* The kilogram weight is the patient weight with an upper limit of 140% of the IBW. The main reason for incorporating the adjusted body weight(ABW) is that their actual weight significantly deviates from the. Drs Nightingale, Trovato, Lee, and Thompson have reported no actual or potential conflicts of interest. Carboplatin is a crystalline powder with the molecular formula of C 6 H 12 N 2 0 4 Pt and a molecular weight of 371.25. The utilization of the Calvert formula in patients with GFR or CRCL <15 to 20 ml/min is not recommended. There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. Carbo dose = target AUC (mg/ml/min) x (CrCl + 25) (ml/min) Please read the disclaimer before using this calculator. Calculation for carboplatin dose (Calvert Equation): Sherif Abdou, Pharm.D, Northwestern Memorial, SCr defaults to 0.7 IF it is lower than 0.7, Adjusted body weight will be used for BMI 25, Any electronic tool, including those found on OncPharm.com, are not substitutes for clinical experience and expertise. Among the AUC-5/6 patients, the CG equation resulted in a broad range of eGFR values varying from approximately 30 to 150 ml/min for the first four carboplatin cycles (Fig. It is calculated by adding Concordance Percent and 0.5 times of Tied Percent. A retrospective analysis was conducted using data from patients who received carboplatin therapy during the period between January 2008 and January 2009. Forty patients with metastatic/locally advanced breast cancer were treated with carboplatin based on glomerular filtration rate (GFR) to achieve an area under the concentration-versus-time curve (AUC) of 7 mg/mL.min, with each course repeated at 4-week intervals. Methods. The normal GFR values are calculated by the carboplatin AUC calculator. An electronic tool cannot assess the clinical picture and patient-specific factors. How to Calculate priceeight Density (Step by Step): Factors that Determine priceeight Classification: Are mentioned priceeight Classes verified by the officials? Existing data comparing the Cockcroft-Gault equation and the MDRD equation for calculating estimated renal function in the Calvert formula were recently published. , who did not report bias or imprecision of their method, and visual inspection of the goodness of fit of the final model. Carboplatin is a chemotherapy drug commonly used to treat ovarian cancer. The Carboplatin calculator determines the therapy AUC dose based on the Cockcroft Gault equation and on target AUC. The actual carboplatin AUC and actual GFR were not measured as part of this analysis. Calvert AH, Newell DR, Gumbrell LA, et al. Cockcroft DW, Gault MH. Actual body weight was applied to the SCr-based formula in 19 patients (95%). Fifty percent of the patients were obese, and the mean BMI was 32.059 kg/m2. Prescribers utilized the Cockcroft-Gault formula to estimate glomerular filtration rate in 100% of the participants (N = 20). Carboplatin dose calculator: Other useful online medical calculators on Online Medical Calculators page. If two or more of the three patients experienced a Grade 3-4 AE during the first . The formula is: dose (mg) = AUC (mg ml-1 min) x [GFR (ml/min) + 25 (ml/min)]. Conclusion: The use of actual body weight in the Cockcroft-Gault equation to estimate glomerular filtration rate in the Calvert formula was associated with a high percentage of adverse clinical events. Drug Calculators. When actual body weight is applied to an SCr-based formula for use in the Calvert formula, overweight and obese patients may have carboplatin AUCs greater than targeted because of overestimation of renal clearance. Jodrell DI, Egorin MJ, Canetta RM, et al. 1. This carboplatin dosing calculator uses the Calvert method to calculate the total carboplatin dose needed to achieve a given AUC (area under the free carboplatin plasma concentration versus time curve) while taking into account renal function. CrCl for female = [ (140 - age) x Weight in kilograms x 1.04] / (Serum Creatinine in mol/L) The ideal body weight by Devine's formula: Male = 50 kg + (2.3 x (Height in inches - 60)) Female = 45.5 kg + (2.3 x (Height in inches - 60)) The ideal weight result is converted in both kg and lbs for convenience, where (1 kg = 2.20462262 lbs). Kidney function was stable for all patients. The chemotherapy combination regimens that each patient received were not well balanced, thus the addition of other cytotoxic chemotherapy agents, such as paclitaxel, increases the risk and severity of myelosuppression when compared with monotherapy. The normal value of GFR > 90 ml/min and 1.73 m2 is considered the normal range of the GFR and we consider the kidney working properly. GFR Stands for Glomerular Filtration Rate(GFR), it speaks about the power or the cleaning ability of the kidneys of patients. Andrew Crawford, Pharm.D, University of Illinois The carbo calculator can be used to find Carboplatin dose (mg) for patients. Carboplatin dose is based on the Calvert formula: Dosage = Target AUC x (GFR* + 25) *Where the GFR is provided by the eCrCl. Split data into two parts - 70% Training and 30% Validation. Carboplatin has been approved by the US Food and Drug Administration for the treatment of ovarian cancer and has been used off-label for the treatment of many solid tumors, including lung, head and neck, endometrial, breast, and cervical cancers.1 As a nonclassical alkylating agent, carboplatin acts by covalently binding to DNA, thereby interfering with the crosslinking and synthesis of DNA and cell replication. The influence of the modality of prescription of carboplatin according to body surface area or to carboplatin clearance related to the renal function was evaluated according to the Calvert AUC-based equation; glomeruler filtration rate (GFR) was evaluated according to the Cockroft formula from the serum creatinine level that was measured before each new cycle of chemotherapy; and carboplatin . A dose reduction was defined as a 20% dose decline or a reduction in the target AUC from the previous dose, with supporting documentation on the chemotherapy order confirming a dose reduction secondary to toxicity. Action letter for protocols sponsored by the National Cancer Institute that use carboplatin. Adults who received at least 1 dose of carboplatin with documentation of desired area under the concentration-time curve were included. 5) AUC-based carboplatin dosing is more accurate than dosing according to BSA. The Glomeruli are the tiniest of filters in our kidneys specially designed to filter our blood from waste. 1989; 7:1748-1756. 3 A). 1997;33:161-183. carboplatin (i.e., AUC) based on patient's renal function (i.e., GFR). Seventy percent of the patients (N = 14) were treated with doublet-combination chemotherapy, and the remaining 30% of patients (N = 6) received a triplecombination chemotherapy regimen. The calculator will readily estimate carboplatin dosage in milligrams by considering your cretanine and targetted AUC value. By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. . The Calvert formula is the preferred method to calculate the dose for a given target AUC. The target AUC chosen was 5 mg/mL/min. To calculate the classification accuracy, you have to predict the class using the machine learning model and compare it with the actual class. (Lancet, 2005), but dose ranges were not reported. Please note that dose is provided in mg not mg/m2. The Jelliffe equation is used by most gynecologic oncology group protocols, and gynecologic malignancies did not comprise our study population, which explains why the equation may not have been used. Prospective studies are needed to substantiate these preliminary clinical data. Whichever method was used, carboplatin AUC was not significantly associated with antitumour response rate nor patient survival. Our results demonstrate that physician prescribers utilized the Cockcroft-Gault equation to estimate GFR in all patients. 7 days from the planned day of carboplatin and target AUC is 5mg/ml/minute and our height is inches. Jakobsen a, et al practice to control plasma drug exposure of carboplatin ovarian Both kg and lbs for convenience, where ( 1 kg = 2.20462262 lbs ) prescribing. Bsa for adult women: 1.6 m2 descriptor applied some statisticians also call it AUROC which stands for filtration. 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