. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. It has shown to be 100% protective of hospitalization in 2 clinical trials. He applied the drug to a large COVID outbreak at Golden Gate Fields just days after the Lenze trial was published. Fluvoxamine was reportedly added to just 2 practice guidelines (. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. We need to keep people out of the hospital in the first place. Doctors have no excuse for not prescribing. If you start 5 days after symptoms, all bets are off. Its whether Merck can make a killing that matters. Discover special offers, top stories, Over the summer, the conflict reached his most recent startup, M10. (Siliciano did not respond to requests for comment for this article.). NIH is still unsure whether fluvoxamine should be used to treat COVID. Some countries dont have fluvoxamine so this is the alternative. Im just telling you the truth. They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. In June, after CETFs advisory board resigned, Kirsch did a Facebook Live video with Zelenko and celebrity rehab coach Dr. Drew. It was so bad you couldnt even see the babys body through all the blood, Kirsch said. Its motivated out of his sense of keeping people safe and advancing health care.. The other doctors aren't using it either because they don't know about it or fear doing anything not approved by the CDC for treating COVID. Dr. Joe Ladapo wrote a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients." The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. In-patient use. This is the gold standard of evidence based medicine. But the potential upsides. Steve Kirsch was extremely helpful early on in the pandemic, stepping up to fund early treatment trials when the US government would not fund such studies, Boulware told me in an email. He is very smart, and he knows that he is very smart, and hesometimes he behaves like he thinks hes the smartest guy in the room, whether he is or isnt, he told me. In severe cases, it takes longer. Its all about NIH saying it is OK. Medicine today is driven by government opinion, not science. Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. At the beginning of the COVID-19 pandemic, Steve Kirsch created the COVID-19 Early Treatment Fund (CETF) to finance trials of off-patent drugs in an attempt to find a potent treatment that had been staring us in the face. This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. Fluvoxamine is the poster child of the COVID-19 Early Treatment Fund (CETF). . I asked to give a talk about COVID at MIT, but they couldn't find a faculty member to sponsor it. It is very important to educate doctors because most people rely on their doctors for advice. Hes very convincing. Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19). We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. I bumped up the reward to $1M. During our first conversation, which turned into a multi-hour Zoom session, Kirsch paced through the rooms of his cavernous house with his phone held at chest level, rarely looking down at the camera. The rest of the board soon followed. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. Stopping the meds will return you to your normal self. The trials that were abandoned for futility werent getting events because the patients were given standard of care meds. The 5 observational studies is icing on the cake. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). There are other non-prescription things you should always have on hand. Another CETF grant, though, yielded far more exciting results. So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. Telling the truth, he tweeted. I agreed to do it partially because I respect Bob [Siliciano] so much, and partially because I thought the concept was excellent, said former board member Doug Richman, a prominent HIV drug researcher at the University of California San Diego and former member of the funds scientific advisory board. He may not be a good scientist, but hes smart, says WVUs Feinberg. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. February 17, 2021. . Although the average effect size is 100% with a p-value of <.0001, The Fisher exact test on the combined data suggests that there is a 95% chance that the effect size is at least a 75% reduction in hospitalization rate. 1. Always be self aware when using fluvoxamine. Everyone says "we need more data" to show fluvoxamine works for COVID. According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. ICER: Hes refused to accept the results of a hydroxychloroquine trial that showed the drug had no value in treating covid, for instance, instead blaming investigators for poor study design and statistical errors. They never make things worse so are safe to try. Dosing. Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. including the very promising Fluvoxamine. . Ive used it personally at 50mg twice a day and experience no adverse events at all. NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). Fluvoxamine has a 40 year safety track record. Can I see your risk-benefit analysis?. 12:45 AM . Part of TV News Archive. And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? Steve Kirsch is a Silicon Valley philanthropist. The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. That was a lie. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. The data is there in plain sight for anyone to see today. He told me that while he and his family got vaccinated as soon as they were eligible, he got the idea that vaccines are dangerous from a man he hired to clean his carpets, who got very sick after receiving the vaccine. Article about the rejection (Stat News) Article about the fluvoxamine rejection (The Verge) NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). After one or two conversations like that, I got tired of arguing, so I started avoiding his calls.. To date, the #1 drug with the most evidence to make a significant difference, without any doubt, is fluvoxamine. I have all of these on hand and I load up on vitamin D3 every day. The documents in the data room discuss all eight (you'll need access to the restricted area to see the presentation on all 8). thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for, because they were rejected by 10 journals. Physicians who use the drug for COVID now swear by it. ). There is no evidence fluvoxamine is harmful and led to a worse outcome. So it was both obvious and convincing the difference between the groups to the workers and the track management. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. Or just depression about the vaccine mandates? The medical community doesnt care about saving lives. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. Even though an expert panel was overwhelmingly convinced in just one hour, hearing a very small subset of all the supporting evidence, the organizations that they belong to are taking their time. In 2013, Johnson & Johnson paid $2.2 billion for its own kickback and fraud scandal, including a specific $400 million fine for its subsidiary Janssen, which manufactures the covid vaccine. Almost 2.5 million people signed up to Dr. B with the promise of getting leftover vaccines. Dr. Eric Lenze: So the results were really pretty. In three phone conversations, as well as dozens of emails, his responses to questions about claims in this story were imprecise or constantly changing. If you continue to get this message, To scientists, giving fluvoxamine a chance means running a large trialnot giving it to individual patients in the clinic, off-label and outside the context of active data collection and analysis. We should be making decisions now based on the evidence on the table today. The web value rate of skirsch.io is 2 . Design thinking was supposed to fix the world. I wanted to get the article out before my flight left. In California, Silicon Valley tech entrepreneur Steve Kirsch was also thinking about the pandemic. Fluvoxamine was reportedly added to just 2 practice guidelines (Ontario and Johns Hopkins). The FDA approved Molnupiravir which was less effective. Its really, really common for a small effect, something that looks exciting, to be a statistical fluke when you look at a larger population. [https://www.quora.com/What-is-the-current-treatment-for-Covid-19/answer/, The most urgent need in the country right now is to reduce. More recently, hes adopted extremist positions on covid vaccines, which he alleges are toxic. He has claimed that one in 1,000 people who have received mRNA vaccines have died as a result, and even claimed the vaccines kill more people than they save at an FDA public forum, which was first reported by the Daily Beast. By Steve Kirsch Last updated: March 14, 2021 After I appeared on the60 Mi nut es story about fluvoxamine,I've received a lot of questions from people about how to treat COVID. Im sorry to sound so cynical. Reason is the hospital gets release from liability if they follow NIH guidelines. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). Links to evidence about fluvoxamine including the public data repository. But the best way to help people is through rigorous trials that show what drugs help which people, and at what doses and timesnot by basing entire protocols on incredibly limited evidence. Doctors who are most familiar with the drug would prescribe it to their patients. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel. It works best when it is given early, as soon as symptoms start. Independent appraisal committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes. Jeffrey Glenn, an infectious disease professor at Stanford University, calls the inaction on the current evidence on the table "criminal.". No long haul symptoms if you start the drug ASAP after first symptoms. I learned this the hard way. May 16, 2022. But even that didnt last long. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown.
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